Edited by: Natalie Geld, MedNeuro, Inc., United States
Reviewed by: Paul Campbell, Amazing Media Group, United States; Nicole Tay, MPH, Science Distributed, United States; Jane Thomason, The University of Queensland, Australia
This article was submitted to Blockchain for Good, a section of the journal Frontiers in Blockchain
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
There are growing initiatives and calls to focus greater attention to the social determinants of health (SDOH) and their impact on population health (
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Social determinants of health (SDOH) have an outsized effect on individual healthcare outcomes. SDOH address the economic and social conditions that influence health status, such as physical environment, education, socioeconomic factors, social support, and access to healthcare services (
A distributed ledger encompasses capabilities to keep a secure tracking of verifiable data. While the identified use cases in healthcare are numerous, one use case stands out in particular—the coordination and access to trusted data in an effort to address the SDOH. Through patient consent and partnership with key healthcare provider and payor stakeholders, a union of electronic health records and claims, and the collection of SDOH related factors and information, it will allow for and enable in-depth scientific analysis examining patient-specific needs, intervention effectiveness, and insights into the needed evolution of healthcare to consider both clinical and social determinants to address the needs of the population.
The integration of SDOH as a clinical requirement using technology requires understanding the important role of place environment and its overall impact on health, well-being, and population-level health outcomes and the current challenges that exist today. Previous research and observations have indicated that many individuals, particularly underserved populations, often have a large distrust of provider systems, including healthcare systems (
In an effort to address the rising cost of healthcare services, reimbursement strategies are emerging by payors and providers, including the advent of value-based reimbursement (
Indeed, there are challenges to the inclusion of SDOH services and activities, not the least that they are often non- or under-reimbursed and are most often provided by government and/or not-for-profit social service agencies that are heavily underfunded, understaffed, or staffed by volunteers. SDOH services are now becoming recognized for the importance of their impact on population health and long-term clinical outcome. Furthermore, there remain numerous questions still to be evaluated as to the prioritization, intervention, data requirements, and unintended consequences brought to bear by the inclusion and integration of SDOH. As healthcare systems have yet to fully achieve a full understanding of their capabilities, management of data, and cost equalization, this necessitates further review of how SDOH has the potential to provide a positive impact on overall health systems and their associated outcomes (
At the time this manuscript was drafted, the world was experiencing one of the deadliest pandemics in centuries, COVID-19. The skyrocketing incidence rate and virulence of the virus had caused almost every country in the world to mandate enforceable self-quarantine and stay-at-home orders to mitigate and flatten the curve of the viral spread. Within a month of the implementation of stay at home or social distancing orders, the global economy had fallen into a recession with the highest levels of unemployment recorded in recent history (
Although not a new technology, blockchain, a type of distributed ledger, has increased in popularity since 2017 as a technology that may prove to have many benefits for the healthcare industry. With secure technology and encryption mechanisms, blockchain can give rise to a new era of digital healthcare technologies with improved access to patient data. The harmonization of this data could have large, positive benefits to supporting the SDOH.
For blockchain, 2018 was no doubt a milestone year. In 2018, over 21 billion USD (
A strong case can be made that social, political, cultural, and economic factors have an effect on health, upward mobility, and quality of life. SDOH in short are “the structural determinants and conditions in which people are born, grow, live, work, and age (
While complex, the association between economic security and health outcomes is well known (
In the United States, approximately 30% of the population is either unbanked (do not have a bank account) or under-banked (have a bank account but is underutilized) (
Factors such as poverty, inadequate employment opportunities, food and housing insecurities, and education opportunity play a significant role in individuals’ experiences and can drive patients to present for care, often much too late (
While blockchain offers solutions, tools, and resources to address and improve health, it is not without challenges. Utilizing blockchain technology in healthcare offers the ability to increase transparency, allow patients to have ownership over their data, and reduce fraud. However, questions remain such as how the use of blockchain technology can lead to improvements in other healthcare access-related barriers, such as patient engagement and patient- and physician-level access, as well as address other SDOH related factors.
The crux of improved patient care is dependent on our ability to link individuals to their individual-level records. For the first time in history, blockchains allow for the automation of the irrefutable trust that that linkage is true. A blockchain is defined as a distributed ledger or an unchangeable (immutable) record of transactions. As an immutable audit trail that allows for programmable contracts (aka smart contracts), blockchains are protocols that create trust (
Blockchain can enable big data and advanced analytics to achieve integrated collaboration and team-based, person-centered, and health-focused care, which are key factors in improving the aforementioned factors. Healthcare, while advanced, is inconsistent in terms of cost, access, and outcomes. Anticipated population growth, demographic change, and advances in medicine and healthcare technology mean that the cost of care is likely to continue to grow, unless we can innovate to deliver better healthcare and better health outcomes while using resources more efficiently. Healthcare needs to go beyond incremental change in an effort to achieve significant and sustainable improvements in the quality of care, population-level health, and affordability. In ensuring a sustainable healthcare infrastructure into the future, innovation is a necessity. A key transformation strategy is to have patients informed, engaged, and activated through evidence-based strategies, consistent with their values, goals, and preferences, and effective in their personal and social milieus (
Empowering individuals, including both patients and providers, through the use of blockchain and artificial intelligence (AI) and machine learning (ML), would potentially allow for the delivery and receipt of the best evidence-based and personalized care across the continuum of care through improved data collection, management, and real-time integration and analysis (
Blockchain also offers solutions to some of the biggest pain points of aggregating data management such as permissions, privacy with zero proof knowledge, and efficient coordination of multiple data sets. Leveraging SDOH requires access to various types of data (e.g., clinical, demographic, geographical, educational, socioeconomic, etc.) (
Therefore, opportunities in leveraging blockchain for SDOH include strengthening existing Health Information Exchanges (HIEs) and the creation of new information exchange system. As part of recent legislation (the 21st Century Cures Act), the Office of the National Coordinator for Health Information Technology (ONC) was charged to develop policies to support the exchange of information on a national scale. The Trusted Exchange Framework and Common Agreement (TEFCA) as proposed by the ONC has proposed a series of health HIEs to address adequate patient matching.
This is now a national imperative in the United States. In regard to improving health information exchanges and capturing patient-level data, an incorruptible distributed ledger (blockchain) offers solutions to many of the pain points in healthcare and public health management such as establishing a trusted network, lowering the cost per transaction, and creating a master patient index. To most effectively leverage the SDOH to improve health and reduce overall burden of costs, it will be necessary to track those determinants at the individual level and to be able to connect, or match, them to other groups to which they might belong. Being able to do so helps to create a clearer and more consistent picture of that individual’s social, cultural, political, economic, and environmental needs, and challenges in relation to maintaining their health, effectively allowing for better individual-level and population-level interventions.
In a 2017 report, Deloitte describes the need for an ecosystem approach (
Connecting the pockets of data among the numerous institutions and services that an individual may frequent for care has been a significant pain point and barrier to developing effective SDOH programs.
Social determinants of health play a large role in preventative health by identifying the social conditions that tend to aggravate or accelerate disease, and provide guidance on interventions that can slow or prevent the onset of disease. Much of this network of factors are poorly tracked and live in siloed pockets of data distributed among a variety of organizations (or departments) involved in the delivery or management of services. Building a behavioral and environmental profile on an individual or group of people is conditional on the ability to link a string of distributed data points in order to start to see the larger story behind an individual’s health needs. Whether in terms of early detection or tracking disease outbreak/progression, vaccination availability and activity, clinical trials, and pharmaceutical tracking and recall, these ongoing public health challenges could all benefit from an immutable ledger of data that cannot be corrupted or altered. The ability it provides in aiding public health officials to be able to move quickly and precisely through the ease of access and secure data is essential in their success in protecting population health overall.
An example of how this can be applied to current workflow systems can be applied to Meals on Wheels. Meals on Wheels, a non-profit delivering meals to America’s seniors also doubles as the only “eyes and ears” for some of the most vulnerable citizens in the United States. Aside from providing meals, they are able to assess seniors’ housing conditions and mental state and offer a bit of companionship at each visit, providing a type of surveillance that is difficult to do at scale. That surveillance, however, has little benefit unless a coordinated safety net system exists when risk indicators present. With this use case, a blockchain solution using hash identifiers for each senior could coordinate siloed data sources to identify those indicators in real time for each person, while utilizing zero knowledge proof to maintain privacy. Furthermore, an AI/ML layer could guide this system to automate the distribution of resources via smart contract programming when those high-risk indicators arise in surveillance. This type of coordinated and automated system currently does not exist and could be streamlined using blockchain or distributed ledger technologies.
In an environment where no single central authority exists and information must be distributed with access to all stakeholders, a blockchain solution can help solve critical problems of trust, consensus, and privacy. However, blockchain alone is insufficient to meet the complex needs of patients, providers, insurers, governments, and the broader network of critical social and community healthcare services. The proposed reference architecture establishes a set of key capabilities and high-level detail of the system components.
Actors:
Patient (caregivers).
Healthcare organizations (healthcare providers).
Social service organization (social service providers).
Trusted Analytics Organization (TAO).
Patient and provider identities Duplicate entity management Lost credentials Linking accounts Delegation |
Permission granted by patient Agreement between wellness and healthcare provider organizations |
Historical tracking of: participants, Measurements Services rendered Assessments of need Updates and record correction Annotation (patient or provider) |
Encryption Secure messaging Provide patient with access to all of their data Retention and data privacy policy Right to be forgotten Right to change data |
Registries Utilization Trends Outlier detection and alerts Impact assessment |
Blockchain technology allows for the decentralized tracking of patient data and provider encounters. The reference architecture is based on a private Ethereum-based network. The blockchain network provides secure transactional capabilities.
Data can be recorded from any organization without need for central administration.
Distribute data (transaction) across multiple locations—there is no dependence on a single hosting organization.
Once entered, data cannot be changed. Corrections can be appended to the chain and new information can be added while maintaining complete historical integrity.
Users can trust transactions without needing to trust the participants or holders of the data.
Shared ownership and validation ensure that a network can persist even if the initial hosting organization disengages.
In the reference architecture, a private Ethereum network is deployed to allow for decentralization and distributed without the transaction cost of a public blockchain. Using a proof of authority (PoA) algorithm provides a more secure, less computationally intensive, and more performant solution than proof of work (PoW) and does not require management of cryptocurrency tokens as would a proof of stake (PoS) approach. Any number of read-only nodes could join the network; however, only authorized ones are explicitly allowed to create new blocks and secure the blockchain. Once a block is signed off by the majority of authorities, it becomes a part of the permanent record. While anyone with access to the network could establish a node, only nodes corresponding to account addresses are stored in a validator contract. While the PoA architecture provides higher transaction volumes and does not require cryptocurrency management, it does forgo some degree of decentralization, but in small regional settings, this may be inevitable if other parties are not capable of hosting their own nodes. In larger communities or regions, the number of participants will provide a significant degree of decentralization.
It should be noted that decentralization is not required for the purposes of improving healthcare outcomes by leveraging the SDOH. It is an inherent aspect of healthcare that must be overcome. Blockchain accommodates a decentralized organizational model and is not being deployed in order to force a decentralized system of care.
The focus of using blockchain in healthcare is to collect patient, provider, and encounter data with a focus on SDOH. The blockchain enables patients, physicians, care coordinators, social services, and caregivers to track encounters, needs, and healthcare outcomes. The blockchain network provides a secure means for accomplishing this. However, in order to derive useful insights from the data collected, additional infrastructure is required. Population health, risk management, intervention and treatment efficacy, and service allocation all require substantial analytical reporting capabilities. ML models, with their ability to extract key insights from the data, are required to be able to understand the relationships between SDOH and health outcomes. These reporting and analytical needs require a data warehouse layer in the reference architecture. Data extraction, exchange, and storage must be implemented with the same focus on security while allowing patients full control and visibility of their data.
A number of smart contracts are required to implement provider and patient setup, account linking, SDOH data collection, data updates to historical transactions, and consent agreement management. Granting consent results in a set of data elements being populated and encrypted in the same manner as the encounter data. A transaction is sent to the TAO account to record the updated consent information for the associated patient. Withdrawal of consent creates a new consent transaction and updates the end date–time field for the patient’s account and sends a new transaction to the TAO’s account recording the new consent status.
Where patient consent exists at the time of transaction, a copy of the data is encrypted using the TAO public key. These data are now safe to send over a public network to be securely managed behind a firewall in a HIPAA-compliant manner. If a patient record does not exist at the time of transaction, government regulations allow for de-identified, anonymized information to be exchanged for the purpose of managing population health and managing social and healthcare services.
Where a Business Associate Agreement exists between the TAO and a healthcare provider, the provider may request records of their transactions for the appropriate patients. Conversely, a healthcare provider may send data to the TAO for the purpose of augmenting reporting or modeling based on the SDOH data and encounter information for the blockchain. Patients may initiate or approve a request for data that use their private key to decrypt a range of historical data from the blockchain and serialize it into an encrypted message to the requestor to be stored off-chain.
Data exported from the blockchain is managed based on consent. A full data set of de-identified data may be stored in a secure data warehousing platform to allow for population health modeling and assessment. A second data set containing Personal Identity Information (PII) is maintained separately. In accordance with HIPAA and established Business Associate Agreements, this data set may be combined with electronic health record, claims, and pharmacy information to provide a more individualized risk assessment and recommendations for services, care programs, and other forms of support. This information helps physicians, clinicians, and other healthcare and service providers to identify key patterns in health, illness, and disease. The data provide a comprehensive picture that can help determine the use of various evidence-based interventions, strategies, and recommendations and the appropriate course of treatment. It may also enable providers to be able to more clearly communicate and allow for patients to have a more involved say in their care. Through the ability to integrate individualized data within the clinical and social context, this will help enable the assessment of broader community-wide efforts to improve population health.
The barriers to data sharing among clinical entities are breaking down as technology solutions become evident and accepted. Blockchain technology provides the means to create a trust protocol verifying identity and transactions. The call for innovative strategies as well as growing case studies and research on feasibility and effectiveness of blockchain should ensure the integration of the five key domains of the SDOH: (1) economic stability, (2) education, (3) health and healthcare, (4) neighborhood and built environment, and (5) social and community context in an effort to target the complexities of prevention and intervention (
Healthcare is advanced but not reliable. Anticipated population growth, demographic change, and advances in medicine and healthcare technology mean that the cost is likely to continue to grow, unless we can innovate to deliver better healthcare and better health outcomes while using resources more efficiently. Healthcare needs to go beyond incremental change to achieve significant and sustainable improvement in quality, population health, and affordability. In ensuring that our healthcare system is sustainable into the future, innovation is a necessity not a luxury. Blockchain can enable big data and advanced analytics to achieve utmost collaboration and team-based, person-centered, and health-focused care. A key transformation is to have patients informed, engaged, and activated through evidence-based strategies, consistent with their values, goals, and preferences, and effective in their personal and social milieus. Empowered and technology-savvy individuals, using blockchain and AI would potentially receive the best evidence-based and personalized care across the continuum of care.
Leadership roles will shift to address new values, new competencies, emerging trends, and demands for consumers as co-designers of care. The incentivization for change lies on the premise of this emerging technology being able to reconcile elusive data for advanced preparation in determining health outcomes. The recent increment in engagement and efforts of the healthcare community combined with recent developments in blockchain technology are creating such new and much-needed opportunities. We recommend further research on the advent of data analytic platforms with blockchain technology. We believe that these data will provide researchers with direction to evaluate the impact of these technologies.
All authors contributed to the overall development, writing and editing of the manuscript.
CM was employed by the company Patientory, Inc. and JC was employed by Moda Health. CM, MF, and JF were board members of the Patientory Association. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.